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BioRender Template
Mode of Action virus protein X (VPX) counteracting SAMHD1
Creator
s
Description
Lentiviral vectors that are loaded with VPX can infect non dividing cells more easily thanks to the inactivation of SAMHD1 by ubiquitination. The nucleotides necessary for reverse transcription becomes available both in the cytosol and nucleus which is why there is no spatial barrier indicating this. VPX blocks the effect of SAMHD1
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