Allergic Airway Sensitization

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Our airways are exposed to allergens regularly. Dendritic cells (DCs) at the airways capture, internalize, and display the allergens on cell surface MHCII molecules. DCs migrate to the lymph node (LN) and encounter T cells specific to the allergen. DCs induce the differentiation of the T cells into Th2 cells. Th2 cells produce cytokines (IL-4, IL-5, IL-13) inducing mucus production and airway smooth muscle contraction. This forms the basis of allergic airway sensitization and asthma development.

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