B Regulatory Cell Surface Receptors Influence IL10-Mediated Immune Tolerance

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Binding of CD38 ligand (CD38L) to CD38 and IL10 to the IL10 receptor (IL10R) on B cells leads to increased expression of IL10 associated genes via the activation of the respective CD38/Syk/ERK/sp1 and IL10/IL10R/JAK/STAT3 pathways. These lead to the production of enhanced anti-inflammatory cytokines as well as the survival family of proteins, Bcl2. In addition, IgM and BAFF/APRIL binding to the B cell receptor and BCMA/TACI, respectively, leads to the activation of Syk/PI3K/AKT and Blimp-1/XBP-1, culminating in the activation of STAT3 and increased IL10 gene expression.

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