Generation of Tumor Mouse Models

This template compares five ways to generate tumor mouse models: genetically engineered mice with an MMTV-X promoter, syngeneic mice implanted with mouse cancer cells, cell line-derived xenografts using human cancer cells in immunodeficient mice, orthotopic implantation of human cancer cells, and patient-derived xenografts made from excised human tumor tissue. Each pathway is shown step by step from the starting cell source through implantation into the appropriate mouse strain.

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