Generations of CAR T Cell

This template shows five generations of chimeric antigen receptor (CAR) T cell design compared to a natural T cell receptor, tracing the addition of components from an ScFv and CD3zeta signaling domain in the first generation to added costimulatory domains, IL-12 inducers, and IL-2Rbeta chains that trigger JAK and STAT3/5 activation in later generations. It notes that CAR T cells and TCRs both rely on CD3zeta signaling domains to activate T cells upon target recognition.

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