Sir2 favors nonselected & disfavors selected aging in budding yeast

a) Replicative aging assay. The longevity benefit of CR—and the effect of SIR2—emerges after ~21.2 cell divisions. b) In a yeast culture mothers who have divided 21.2 times constitute 1 in 4.8 million cells. Because a yeast culture can be regenerated from any cell, this is not a selected trait. c) Yeast have been cultured from dried flasks for millennia such that chronological aging is a selected trait.

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