The Role of Ubiquitin (Ub) in EGFR Trafficking

This template shows how EGF binding and EGFR dimerization lead to receptor phosphorylation and ubiquitination by c-Cbl, followed by internalization into an endosome. Depending on whether ubiquitin is removed or persists on the receptor, the EGFR is then recycled back to the membrane as a monomer or degraded within the endosome.

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