Negative Feedback in Molecular Stress Signaling

This template shows the hypothalamic-pituitary-adrenal axis, where the hypothalamus releases CRH to stimulate the pituitary gland's ACTH release, which in turn triggers adrenal cortex secretion of cortisol. Cortisol binds a glucocorticoid receptor complex with FKBP51 or FKBP52 that translocates to the nucleus and induces FKBP5 transcription, and it also feeds back to inhibit the hypothalamus and pituitary gland in a negative feedback loop.

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