A Potent Melanocortin MC3 and MC4 Receptor Antagonist: SHU-9119

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Melanocortin (MC) receptors are G protein-coupled receptors that are regulated by both endogenous agonists and inverse agonists released from proopiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, respectively. Upon activation, these G protein-coupled receptors may be associated with five types of G proteins: Gsα, Giα, Gqα, Gtcα, or Gzα. The Melanocortin System. POMC is the precursor of the melanocortin. Drug design for SHU-9119 bases on peptide mimetics of α-MSH.

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