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Description: This template shows how five drug therapeutic types, small molecules, proteins and peptides, antibodies, nucleic acids, and live cells, each face specific formulation challenges, which are addressed through either drug modifications like PEGylation and antibody humanization or environmental modifications like pH adjustment and permeation enhancement. Both modification paths feed into a shared set of commercial drug delivery systems, including microneedle patches, nanoparticles, transdermal patches, and drug-loaded contact lenses.