Detection of Bacterial Peptidoglycan by NOD Receptors

This template shows how NOD1/2 receptors detect bacterial peptidoglycan fragments in the cytoplasm in five steps. Binding of bacterial ligands iE-DAP or MDP induces NOD homo-oligomerization, recruitment of RIPK2, and activation of TAK1 and the IKK complex, leading to IkB degradation and NF-kB translocation to the nucleus.

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