Dynamic Reciprocity in the Ovarian Extracellular Matrix (ECM)

The ovarian tissue-specific ECM can serve as an organic scaffold for in vitro follicle growth, due to its native ECM glycoproteins, regulators, affiliated proteins, collagens, proteoglycans and other secreted factors that facilitate an important crosstalk between the ovarian cells and the ECM. The ovarian cells can synthesize, degrade, and remodel the ECM, regulating its density, and in turn, the ECM provides cues for several cellular processes​​.

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