Effects of Adenosine from the Tumor Microenvironment

Adenosine, released by various cells within the tumor microenvironment, modulates local immune responses. This molecule impacts B lymphocytes, T lymphocytes, natural killer cells, macrophages, dendritic cells, and myeloid-derived suppressor cells, leading to immunosuppression favoring tumor growth. Moreover, the interactions between cancer-associated fibroblasts, pericytes, and extracellular matrix components are influenced by adenosine, which can promote cancer cell survival and invasion. Understanding adenosine's role in the tumor microenvironment provides a basis for identifying potential therapeutic targets for cancer immunotherapy. [Adapted from GPT4, 2023]

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