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Description: This template outlines how exercise affects cancer cells through two main routes: regulation of tumor angiogenesis and vasculature via mechanical and metabolic stress, eNOS-derived nitric oxide, and myokines or adipokines, and regulation of the tumor microenvironment via increased blood perfusion, drug concentration, immune cell activity, and altered tumor metabolism. Each numbered mechanism links exercise-induced molecular changes to outcomes like reduced hypoxia, reduced treatment resistance, and reduced metastasis.