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Description: This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication.
The histological evolution of acute myocardial infarction can be divided in four main phases: firstly, the deformation of cardiomyocytes with the beginning of the necrotic coagulation, followed by the infiltration of neutrophils and the removal of the necrotic cells. Eventually, granulation tissue forms and macrophages, fibroblasts, and collagenous fibers start to appear. It is gradually replaced by a fibrous scar.