Leukocyte Extravasation - The Role of Glycans in Inflammation

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The movement of white blood cells (WBC) from the circulatory system to a site of inflammation is known as leukocyte extravasation. Released immune chemokines initiate expression of selectins on endothelial surfaces which have high affinity for Sialyl Lewis X glycan epitopes. This interaction facilitates endothelial adhesion and leukocyte movement towards the site of inflammation. For lymphocytes (a subtype of WBC), the selectin and glycan are found on opposite surfaces for the same interaction.

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