Metastasis to Bone Disrupts Bone Homeostasis

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Bone homeostasis balances bone building by osteoblasts (OBs) and absorption by osteoclasts (OCs). Bone is a common metastatic site for breast cancers (BCs). BC cells induce OBs to secrete RANKL, which bind RANK on OCs increasing OC proliferation. Increased OC activity elicits greater resorption, releasing pro-tumorigenic growth factors. This vicious cycle causes bone loss and BC growth. Drugs break this cycle by inducing OC apoptosis (bisphosphonates) or inhibiting OC proliferation (denosumab).

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

Yes, BioRender icons and templates meet journal, grant, and copyright standards for publication, and many researchers cite BioRender directly in their figure legends.

Unlock publication permissions with a paid plan, and include 'Created with BioRender.com' in your figure legend, or cite BioRender directly per your journal's guidelines.

Researchers and scientists use this template for publications, funding proposals, grant applications, presentations, posters, and more.