Progression of Parkinson's Disease in the Substantia Nigra

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Parkinson's Disease is a complex, progressive neurodegenerative disease involving loss of dopaminergic neurons and Lewy bodies, which are aggregations of alpha synuclein protein clusters bound to ubiquitin. While the mechanism is not fully understood, Lewy bodies are thought to damage dopaminergic neurons when they form in the substantia nigra and interfere with pathways responsible for motor function and other cognitive processes.

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