SARS-CoV-2 Targeting of ACE2 Receptor and Entry in Infected Cell

This template shows how SARS-CoV-2 enters host cells through the ACE2 receptor, starting with a negative-stain electron microscopy image of the virus binding ACE2 and structural models of the prefusion spike glycoprotein and the receptor-binding domain in complex with ACE2. Two panels on the right show the spike protein's S1 subunit engaging ACE2 and TMPRSS2 at the cell surface, followed by viral entry and internalization leading to viral replication.

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