T cell activation and differentiation

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Signal 1 (binding of the T-cell receptor (TCR) to the peptide-MHCII complex on the antigen-presenting cell (APC) surface) and signal 2 (binding of the T-cell co-receptor CD28 to CD80/CD86 on the APC surface) are required for T-cell activation. The binding of polarizing cytokines to their respective receptor on the T cell surface represents signal 3. Different combinations of these cytokines influence T cell differentiation into distinct effector T cell subtypes that produce signature cytokines.

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