TALE-based Applications

This figure illustrates three key applications of TALE (Transcription Activator-Like Effector) technology in molecular biology. The first section details DNA cutting, where TALE repeats linked to a FokI nuclease induce a site-specific double-strand break in DNA. The second section describes single-base DNA editing, highlighting how TALE-guided binding facilitates the localized action of a deaminase. The final section focuses on epigenetic modulation, which showcases the fusion of TALE repeats with modifiers to target specific genomic loci.

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