The Inflammatory Response

The inflammatory response is initiated in three steps. In (1), initial entry of pathogens leads macrophages and neutrophils to release inflammatory cytokines and histamines. These in turn serve to recruit immune cells and increase vascular permeability. (2) With immune recruitment, neutrophils serve to clear the pathogens as infiltrating monocytes differentiate into macrophages and release tissue healing factors. (3) Following pathogen removal, pathogens are cleared and neutrophils and macrophages exit the inflammation site and move back into the bloodstream.

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