The Process of Sprouting Angiogenesis in a Healthy Blood Vessel

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Angiogenesis occurs in regions of low O2, which induces vascular endothelial growth factor (VEGF) production in tissues. VEGF binds to VEGF receptor 2 (VEGFR2) on the surface of endothelial cells (ECs), triggering competition between neighboring cells as they differentiate. Briefly, VEGFR2 signaling promotes tip cell differentiation, while simultaneously inhibiting tip cell formation in adjacent cells via notch signaling. Notch induces the downregulation of VEGFR2 and induces expression of sVEGFR1, which sequesters VEGF and prevents over-vascularization. Thus, these adjacent cells instead become stalk cells and form the body of the sprouting vessel.

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

Yes, BioRender icons and templates meet journal, grant, and copyright standards for publication, and many researchers cite BioRender directly in their figure legends.

Unlock publication permissions with a paid plan, and include 'Created with BioRender.com' in your figure legend, or cite BioRender directly per your journal's guidelines.

Researchers and scientists use this template for publications, funding proposals, grant applications, presentations, posters, and more.