The Role of CGRP and the Trigeminal System in Migraine Pathophysiology

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The trigeminovascular system is involved in the regulation of the cranial vasculature and is a key element in the transmission of pain. A growing body of evidence indicates that the calcitonin gene-related peptide (CGRP), widely expressed in trigeminal nerve fibers, acts as a principal mediator of migraine. CGRP release from the peripheral terminals initiates a cascade of events, leading to vasodilation of the cerebral arteries and the phenotypic expression of migraine pain.

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