TI-2 Antigens and Cytokine-induced B-cell Activation

This template compares two pathways of B cell activation by TI-2 antigens, showing that TI-2 antigens alone signal B cells through Signal 1 to produce pentameric IgM via a plasma cell, while activated dendritic cells releasing the cytokine BAFF provide a second signal that drives class switching to monomeric IgG. The two panels label bacterial surface antigens as an example of TI-2 antigens and depict the B cell and dendritic cell interaction.

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