Vitamin D Deficiency Impacts Immunity in the Gut

This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. Vitamin D is a key regulator of gastrointestinal immunity. Vitamin D deficiency leads to a disruption in the intestinal barrier, allowing Proteobacteria to enter the lamina propria and cause severe inflammation. Futhermore, a lack of vitamin D leads to an increase in secretion of pro-inflammatory cytokines including IL-17 and IFNy and a decrease in anti-inflammatory cytokines such as IL-10 and IL-22. Together, these result in compromised immune responses.

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