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4 Mechanisms of Action of Trastuzumab

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Description: This template shows four mechanisms of action of the antibody trastuzumab against HER2 on tumor cells, including blocking cleavage of the HER2 extracellular domain, blocking HER2 dimerization with HER1, HER3, or HER4, promoting HER2 endocytosis and degradation, and activating antibody-dependent cell-mediated cytotoxicity by immune effector cells. Each mechanism is shown as a separate panel illustrating its effect on tumor-cell signaling or survival.

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What does the 4 Mechanisms of Action of Trastuzumab template show?

This template shows four mechanisms of action of the antibody trastuzumab against HER2 on tumor cells, including blocking cleavage of the HER2 extracellular domain, blocking HER2 dimerization with HER1, HER3, or HER4, promoting HER2 endocytosis and degradation, and activating antibody-dependent cell-mediated cytotoxicity by immune effector cells. Each mechanism is shown as a separate panel illustrating its effect on tumor-cell signaling or survival.

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