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Anti-Adipogenic Effect of miRNA-27a/cNLC Complexes in 3T3-L1 Cells

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Amina Tucak-Smajić

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Description: This template shows a cationic nanostructured lipid carrier (cNLC) loaded with miRNA-27a interacting with and being internalized by the membrane of 3T3-L1 preadipocytes, followed by endosomal escape of the miRNA into the cytoplasm. Released miRNA-27a inhibits PPARgamma and C/EBPalpha, blocking activation of adipogenic genes and inhibiting lipid droplet formation.

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What does the Anti-Adipogenic Effect of miRNA-27a/cNLC Complexes in 3T3-L1 Cells template show?

This template shows a cationic nanostructured lipid carrier (cNLC) loaded with miRNA-27a interacting with and being internalized by the membrane of 3T3-L1 preadipocytes, followed by endosomal escape of the miRNA into the cytoplasm. Released miRNA-27a inhibits PPARgamma and C/EBPalpha, blocking activation of adipogenic genes and inhibiting lipid droplet formation.

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