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Extracellular K+ Dampens T Cell Functions in the Tumor Microenvironment

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AIK SENG NG

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Description: Necrotic tumor cells release intracellular potassium [K+]i, raising extracellular K+ ([K+]e) in the tumor microenvironment (TME) to 40–50 mM (high-[K+]e). The template shows that high-[K+]e inhibited T-cell cytokine production and dampened cytotoxicity, by modulating the Akt signaling pathway. High-[K+]e also caused significant upregulation of immune checkpoint protein PD-1 in activated T cells. To this end, a novel KCa3.1 activator, SKA-346, rescued T cells from high-[K+]e mediated suppression.

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What does the Extracellular K+ Dampens T Cell Functions in the Tumor Microenvironment template show?

Necrotic tumor cells release intracellular potassium [K+]i, raising extracellular K+ ([K+]e) in the tumor microenvironment (TME) to 40–50 mM (high-[K+]e). The template shows that high-[K+]e inhibited T-cell cytokine production and dampened cytotoxicity, by modulating the Akt signaling pathway. High-[K+]e also caused significant upregulation of immune checkpoint protein PD-1 in activated T cells. To this end, a novel KCa3.1 activator, SKA-346, rescued T cells from high-[K+]e mediated suppression.

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