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Mechanism of Cysteine Protease

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Description: This template shows the mechanism of cysteine protease activity within an enzyme's active site, where a histidine residue deprotonates the cysteine thiol so it can attack the carbonyl carbon of a peptide substrate bond. Curved red arrows trace the electron movement from the cysteine sulfur to the substrate carbonyl and from the carbonyl oxygen outward.

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What does the Mechanism of Cysteine Protease template show?

This template shows the mechanism of cysteine protease activity within an enzyme's active site, where a histidine residue deprotonates the cysteine thiol so it can attack the carbonyl carbon of a peptide substrate bond. Curved red arrows trace the electron movement from the cysteine sulfur to the substrate carbonyl and from the carbonyl oxygen outward.

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