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Potential Strategies for Inducing the Intrinsic Apoptotic Pathway of Cancer Cells

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Martina Maritan

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Description: This template outlines four strategies for inducing the intrinsic apoptotic pathway in cancer cells, including upregulating pro-apoptotic proteins like BAX and PUMA, targeting cellular epigenetics through metabolic pathway inhibition, downregulating pro-survival BCL-2 family proteins like MCL-1 and BCL-XL, and inhibiting transcription factors like Myc and NF-kB. Each quadrant lists example drug classes such as HDAC inhibitors, BH3-mimetic drugs, and PI3K/AKT pathway inhibitors.

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This template outlines four strategies for inducing the intrinsic apoptotic pathway in cancer cells, including upregulating pro-apoptotic proteins like BAX and PUMA, targeting cellular epigenetics through metabolic pathway inhibition, downregulating pro-survival BCL-2 family proteins like MCL-1 and BCL-XL, and inhibiting transcription factors like Myc and NF-kB. Each quadrant lists example drug classes such as HDAC inhibitors, BH3-mimetic drugs, and PI3K/AKT pathway inhibitors.

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