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Protease Inhibitors, Saquinavir and Darunavir, Inhibit Oligodendrocyte Maturation

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Description: This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The antiretroviral drugs, saquinavir (SQV) and darunavir (DRV), inhibit oligodendrocyte maturation through decreasing the acidity of endolysosomes. This SQV- and DRV-driven inhibition can be rescued by MLSA1, a TRPML agonist, by regulating the endolysosomal pH during oligodendrocyte differentiation.

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This template was adapted from the original submission. Edits were made to enhance scientific accuracy, optimal usability and/or to meet industry-leading design standards for science communication. The antiretroviral drugs, saquinavir (SQV) and darunavir (DRV), inhibit oligodendrocyte maturation through decreasing the acidity of endolysosomes. This SQV- and DRV-driven inhibition can be rescued by MLSA1, a TRPML agonist, by regulating the endolysosomal pH during oligodendrocyte differentiation.

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