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Exploring Potential Renal Effects of Dipeptidyl-Peptidase-4 Inhibitors (DPP-4is)

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Mariateresa Zicarelli

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BioRender Team

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Description: Dipeptidyl-peptidase-4 inhibitors (DPP-4is) are non-insulin glucose-lowering agents, belonging to the incretin family, able to improve glycaemic control with a favorable safety profile. They are associated with a low risk of hypoglycemia, no weight gain, and good tolerability in patients with chronic kidney disease. Some experimental and clinical studies suggest that DPP-4is may exert significant pleiotropic effects, in particular on kidneys, but data from clinical trials are still controversial.

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Dipeptidyl-peptidase-4 inhibitors (DPP-4is) are non-insulin glucose-lowering agents, belonging to the incretin family, able to improve glycaemic control with a favorable safety profile. They are associated with a low risk of hypoglycemia, no weight gain, and good tolerability in patients with chronic kidney disease. Some experimental and clinical studies suggest that DPP-4is may exert significant pleiotropic effects, in particular on kidneys, but data from clinical trials are still controversial.

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