Alternative Splicing of Chromatin Remodeling Genes During Sex Reversal

This template shows how the genes JARID2 and KDM6B undergo intron retention at moderate temperatures, producing an untranslated mRNA and a truncated C-terminal isoform, versus transcription from an alternate site at high temperatures that produces N-terminal isoforms altering H3K27me3 methylation of target genes. These alternate splicing outcomes are linked to temperature-dependent sex reversal, since the high-temperature isoforms alter PRC2 binding or methylation marks on target genes.

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