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Alternative Splicing of Chromatin Remodeling Genes During Sex Reversal

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Clare Holleley

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Description: This template shows how the genes JARID2 and KDM6B undergo intron retention at moderate temperatures, producing an untranslated mRNA and a truncated C-terminal isoform, versus transcription from an alternate site at high temperatures that produces N-terminal isoforms altering H3K27me3 methylation of target genes. These alternate splicing outcomes are linked to temperature-dependent sex reversal, since the high-temperature isoforms alter PRC2 binding or methylation marks on target genes.

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What does the Alternative Splicing of Chromatin Remodeling Genes During Sex Reversal template show?

This template shows how the genes JARID2 and KDM6B undergo intron retention at moderate temperatures, producing an untranslated mRNA and a truncated C-terminal isoform, versus transcription from an alternate site at high temperatures that produces N-terminal isoforms altering H3K27me3 methylation of target genes. These alternate splicing outcomes are linked to temperature-dependent sex reversal, since the high-temperature isoforms alter PRC2 binding or methylation marks on target genes.

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