Anti-tumor & Pro-tumor Activity of B cells in the Cancer Tumor Microenvironment

This figure illustrates the dual roles of B cells in the tumor microenvironment. On the anti-tumor side, B cells differentiate into plasma cells, produce antibodies targeting neoantigen-expressing tumors, and activate immune responses leading to tumor cell death. In contrast, B cells can differentiate into regulatory B cells (Breg cells, CD19+, CD24+, CD38+), which secrete cytokines like IL10, IL35, and TGF-β, promoting CD4+ T cell proliferation and upregulating PD-1/PD-L1 pathways, thereby suppressing anti-tumor immunity. Additionally, plasma cells on the pro-tumor side produce antibodies that form circulating immune complexes, leading to inflammation. The balance between these activities influences cancer progression.

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

Yes, BioRender icons and templates meet journal, grant, and copyright standards for publication, and many researchers cite BioRender directly in their figure legends.

Unlock publication permissions with a paid plan, and include 'Created with BioRender.com' in your figure legend, or cite BioRender directly per your journal's guidelines.

Researchers and scientists use this template for publications, funding proposals, grant applications, presentations, posters, and more.