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Anti-tumor & Pro-tumor Activity of B cells in the Cancer Tumor Microenvironment
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Description
This figure illustrates the dual roles of B cells in the tumor microenvironment. On the anti-tumor side, B cells differentiate into plasma cells, produce antibodies targeting neoantigen-expressing tumors, and activate immune responses leading to tumor cell death. In contrast, B cells can differentiate into regulatory B cells (Breg cells, CD19+, CD24+, CD38+), which secrete cytokines like IL10, IL35, and TGF-β, promoting CD4+ T cell proliferation and upregulating PD-1/PD-L1 pathways, thereby suppressing anti-tumor immunity. Additionally, plasma cells on the pro-tumor side produce antibodies that form circulating immune complexes, leading to inflammation. The balance between these activities influences cancer progression.
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