Microglia Activation

This template shows resting microglia becoming activated toward either a proinflammatory M1 state, triggered by MAMPs, IFN-gamma, and GM-CSF and releasing cytokines like IL-1beta and TNF-alpha that lead to a degenerated neurotoxic neuron, or an anti-inflammatory M2 state, triggered by IL-4, IL-10, and IgG and releasing factors like IL-10 and TGF-beta that support a healthy neuroprotective neuron. A surveillance function mediated by CSF1R, SIRP1A, CX3CL1, and CD200R is also shown feeding back to resting microglia.

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

Yes, BioRender icons and templates meet journal, grant, and copyright standards for publication, and many researchers cite BioRender directly in their figure legends.

Unlock publication permissions with a paid plan, and include 'Created with BioRender.com' in your figure legend, or cite BioRender directly per your journal's guidelines.

Researchers and scientists use this template for publications, funding proposals, grant applications, presentations, posters, and more.