miRNA Activity Suppression with miRNA Sponges

This template compares gene silencing with and without a miRNA sponge, showing that without a sponge, miRNA loads onto the AGO-containing RISC complex and binds target mRNA to cause translational repression and mRNA degradation. When a miRNA sponge is present, it sequesters the miRNA and prevents RISC complex formation, relieving translational repression of the target mRNA.

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