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Epigenetic Deregulation in Cancer

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Description: This template shows three mechanisms of epigenetic deregulation in cancer: chromatin remodeling, where loss of H4K20me3 and gain of H4K16Ac through HAT and KDM6/4 activity increases transcription at enhancers and promoters, and DNA methylation, where reduced SAM leads to loss of methyl groups and aberrant gene transcription. It also shows non-coding RNA regulation, where lncRNA affects PolII-driven transcription and miRNA loss alters mRNA stability and translation of oncogenic gene targets.

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What does the Epigenetic Deregulation in Cancer template show?

This template shows three mechanisms of epigenetic deregulation in cancer: chromatin remodeling, where loss of H4K20me3 and gain of H4K16Ac through HAT and KDM6/4 activity increases transcription at enhancers and promoters, and DNA methylation, where reduced SAM leads to loss of methyl groups and aberrant gene transcription. It also shows non-coding RNA regulation, where lncRNA affects PolII-driven transcription and miRNA loss alters mRNA stability and translation of oncogenic gene targets.

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