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Ferroptosis Signaling Pathway

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Description: This template shows how transferrin-bound iron is taken up through the transferrin receptor and processed by STEAP3 and DMT1 into a labile iron pool that drives lipid peroxidation via the Fenton reaction, lipoxygenases, and P450 oxidoreductase. In parallel it shows the glutamate-cystine antiporter and glutamine uptake feeding glutathione synthesis, which GPX4 normally uses to block lipid peroxidation, with disruption of this pathway leading to ferroptosis.

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What does the Ferroptosis Signaling Pathway template show?

This template shows how transferrin-bound iron is taken up through the transferrin receptor and processed by STEAP3 and DMT1 into a labile iron pool that drives lipid peroxidation via the Fenton reaction, lipoxygenases, and P450 oxidoreductase. In parallel it shows the glutamate-cystine antiporter and glutamine uptake feeding glutathione synthesis, which GPX4 normally uses to block lipid peroxidation, with disruption of this pathway leading to ferroptosis.

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