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Integrated Stress Response

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Anna Van Den Berg Van Saparoea

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BioRender Team

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Description: This template shows the integrated stress response, tracing four distinct stress signals, low heme sensed by HRI, viral dsRNA sensed by PKR, uncharged tRNA sensed by GCN2, and misfolded proteins sensed by PERK, that all converge on eIF2-alpha phosphorylation. This phosphorylation blocks general cap-dependent translation while enabling selective ATF4 translation, which drives GADD34 and other stress-induced genes.

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BioRender-Vorlagen-FAQs

What does the Integrated Stress Response template show?

This template shows the integrated stress response, tracing four distinct stress signals, low heme sensed by HRI, viral dsRNA sensed by PKR, uncharged tRNA sensed by GCN2, and misfolded proteins sensed by PERK, that all converge on eIF2-alpha phosphorylation. This phosphorylation blocks general cap-dependent translation while enabling selective ATF4 translation, which drives GADD34 and other stress-induced genes.

Is the Integrated Stress Response template free to use?

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

Can I edit or customize this template?

Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

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How do I cite BioRender if I use this template?

Unlock publication permissions with a paid plan, and include 'Created with BioRender.com' in your figure legend, or cite BioRender directly per your journal's guidelines.

What is Integrated Stress Response used for / who typically uses this template?

Researchers and scientists use this template for publications, funding proposals, grant applications, presentations, posters, and more.