Integrated Stress Response
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Description:
This template shows the integrated stress response, tracing four distinct stress signals, low heme sensed by HRI, viral dsRNA sensed by PKR, uncharged tRNA sensed by GCN2, and misfolded proteins sensed by PERK, that all converge on eIF2-alpha phosphorylation. This phosphorylation blocks general cap-dependent translation while enabling selective ATF4 translation, which drives GADD34 and other stress-induced genes.
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This template shows the integrated stress response, tracing four distinct stress signals, low heme sensed by HRI, viral dsRNA sensed by PKR, uncharged tRNA sensed by GCN2, and misfolded proteins sensed by PERK, that all converge on eIF2-alpha phosphorylation. This phosphorylation blocks general cap-dependent translation while enabling selective ATF4 translation, which drives GADD34 and other stress-induced genes.