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Killing of Stressed Epithelia by Intraepithelial Lymphocytes (IEL)

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Akiko Iwasaki
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Description: This template shows in three panels how intraepithelial lymphocytes (IELs) kill stressed gut epithelial cells, starting with epithelial cells expressing MIC-A and MIC-B in response to a gliadin peptide or other stressor. NKG2D on the IEL binds these stress ligands while CD8 alpha:alpha binds TL, and the activated IEL then kills the stressed cell using the perforin/granzyme pathway.

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What does the Killing of Stressed Epithelia by Intraepithelial Lymphocytes (IEL) template show?

This template shows in three panels how intraepithelial lymphocytes (IELs) kill stressed gut epithelial cells, starting with epithelial cells expressing MIC-A and MIC-B in response to a gliadin peptide or other stressor. NKG2D on the IEL binds these stress ligands while CD8 alpha:alpha binds TL, and the activated IEL then kills the stressed cell using the perforin/granzyme pathway.

Is the Killing of Stressed Epithelia by Intraepithelial Lymphocytes (IEL) template free to use?

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

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Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

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What is Killing of Stressed Epithelia by Intraepithelial Lymphocytes (IEL) used for / who typically uses this template?

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