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BioRender Template
Killing of Stressed Epithelia by Intraepithelial Lymphocytes (IEL)
Description
This template shows in three panels how intraepithelial lymphocytes (IELs) kill stressed gut epithelial cells, starting with epithelial cells expressing MIC-A and MIC-B in response to a gliadin peptide or other stressor. NKG2D on the IEL binds these stress ligands while CD8 alpha:alpha binds TL, and the activated IEL then kills the stressed cell using the perforin/granzyme pathway.
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