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Regulation of p53 by MDM2

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Wendy Jiang
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Description: This template shows how a DNA damage stimulus activates p53, while an oncogene activation stimulus signals through ARF to inhibit MDM2, both converging on p53-driven transcriptional activation of target genes in the nucleus. MDM2 also ubiquitinates p53 to promote its proteasomal degradation, forming a negative feedback loop between p53 and MDM2.

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What does the Regulation of p53 by MDM2 template show?

This template shows how a DNA damage stimulus activates p53, while an oncogene activation stimulus signals through ARF to inhibit MDM2, both converging on p53-driven transcriptional activation of target genes in the nucleus. MDM2 also ubiquitinates p53 to promote its proteasomal degradation, forming a negative feedback loop between p53 and MDM2.

Is the Regulation of p53 by MDM2 template free to use?

Yes, you can customize this template with a free BioRender account (no credit card required). Paid plans unlock additional export formats, higher-resolution downloads, and publication permissions.

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Yes, every element is fully editable. Icons, labels, colors, arrows, shapes and layout can all be changed to match your preferences or needs using BioRender's drag-and-drop editor. You can add or remove elements to fully customize your use case.

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Researchers and scientists use this template for publications, funding proposals, grant applications, presentations, posters, and more.

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