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Immunoproteasomal Processing of IsoLG-Adducted Proteins in Hypertension

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David Glenn Harrison, MD

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Description: IsoLG-modified proteins inhibit the constitutive proteasome, while the immunoproteasome is upregulated in hypertension to process these proteins into IsoLG-peptide adducts. In dendritic cells and endothelial cells, these adducts are presented to T cells. This figure is adapted from figure 6 of the article 'Immune Mechanisms in Hypertension'.

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IsoLG-modified proteins inhibit the constitutive proteasome, while the immunoproteasome is upregulated in hypertension to process these proteins into IsoLG-peptide adducts. In dendritic cells and endothelial cells, these adducts are presented to T cells. This figure is adapted from figure 6 of the article 'Immune Mechanisms in Hypertension'.

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