Modèle BioRender

The p53-Mediated Response

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Eunice Huang

•

BioRender Team

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Description: This figure illustrates the cellular stress response mediated by the tumor suppressor protein p53. Various stress signals (DNA damage, hypoxia, oxidative stress, etc.) activate p53 through phosphorylation/acetylation events. Activated p53 triggers transcription of specific target genes that regulate critical cellular processes, including cell cycle arrest (e.g., p21, 14-3-3σ), DNA repair (Gadd45a, Ddb2), apoptosis (Puma, Bax), senescence (Pai1, Cdkn1α), anti-angiogenesis (Tsp1, Bai1), autophagy (Atg10, Tsc2), and metabolism regulation (Tigar, Gls2). Each pathway ensures cellular adaptation to stress, promoting survival or programmed cell death when necessary.

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What does the The p53-Mediated Response template show?

This figure illustrates the cellular stress response mediated by the tumor suppressor protein p53. Various stress signals (DNA damage, hypoxia, oxidative stress, etc.) activate p53 through phosphorylation/acetylation events. Activated p53 triggers transcription of specific target genes that regulate critical cellular processes, including cell cycle arrest (e.g., p21, 14-3-3σ), DNA repair (Gadd45a, Ddb2), apoptosis (Puma, Bax), senescence (Pai1, Cdkn1α), anti-angiogenesis (Tsp1, Bai1), autophagy (Atg10, Tsc2), and metabolism regulation (Tigar, Gls2). Each pathway ensures cellular adaptation to stress, promoting survival or programmed cell death when necessary.

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