Process of Blood Clot Formation
Description
Ischemic stroke arises due to blockage in the blood vessel and the removal of blockage helps to reduce the damage in the peri-infarct region. Tissue plasminogen activator (tPA) is the FDA approved drug for treating ischemic stroke. Tissue plasminogen activator activates fibrin bound plasminogen into plasmin. Plasmin degrades the fibrin network into a degradable form. The free tPA and plasmin in the circulation is inactivated by Plasminogen Activator Inhibitor 1 and α2 antiplasmin respectively.
Acknowledgements
References
Kaviarasi, S., Yuba, E., Harada, A., & Krishnan, U. M. (2019). Emerging paradigms in nanotechnology for imaging and treatment of cerebral ischemia. Journal of Controlled Release, 300, 22-45.
https://doi.org/10.1016/j.jconrel.2019.02.031
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