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Anti-tumorigenic and Pro-tumorigenic Functions of TAMs.
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Description
Tumour-educated macrophages can promote (left) or suppress (right) tumour development, depending on their activation status and environmental cues. Anti-tumour macrophages can induce cancer cell death via secretion of mediators or through direct cellular interactions. On the other hand, pro- tumour
TAMs can mediate immunosuppression by secreting factors into the TME and expressing surface molecules that lead to recruitment of Tregs and inhibition of CTLs.
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